Pathogenesis of Calcific Aortic Valve Stenosis
From: I. Medizinische Klinik, Universitätsklinikum Mannheim, Mannheim. jens.kaden@med.ma.uni-heidelberg.de
Herz
- Publish Date: Oct 2006
- ISSN: 0340-9937
- Volume: 31
- Issue: 7
- Pages: 620-8
- Medium: Print
- Language:
- Citation (JAMA): Kaden Jens J, et al. Pathogenesis of Calcific Aortic Valve Stenosis. Oct 2006;31:620-8
Abstract
Calcific aortic valve stenosis is the most common heart valve disorder in the elderly and the most common cause of heart valve replacement in industrialized countries. For decades, it was considered a passive age-dependent degeneration of the valve tissue. Newer studies have shown, however, that the pathologic changes in calcific aortic valve stenosis are based on an actively regulated process of matrix remodeling and biomineralization. This review summarizes the currently available data and gives an outlook on potential therapeutic approaches.
Mesh Headings (Keywords): Age Factors, Aged, Aged, 80 and over, Animals, Antilipemic Agents, Aortic Valve, Aortic Valve Stenosis, Calcinosis, Controlled Clinical Trials as Topic, Data Interpretation, Statistical, Disease Models, Animal, Disease Progression, Extracellular Matrix, Female, Humans, Male, Middle Aged, Minerals, Prognosis, Retrospective Studies, Risk Factors, Sex Factors, Smoking
Check for Full Text / PubMed Unique Identifier (PMID): 17072774
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