Combinatorial Expression Patterns of Heparan Sulfate Sulfotransferases in Zebrafish: Ii. The 6-o-sulfotransferase Family.
From: Huntsman Cancer Institute, Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA.
Developmental dynamics : an official publication of the American Association of Anatomists
- Publish Date: Dec 2006
- ISSN: 1058-8388
- Volume: 235
- Issue: 12
- Pages: 3432-7
- Medium: Print
- Language: English
- Citation (JAMA): Cadwallader Adam B, Yost H Joseph, et al. Combinatorial Expression Patterns of Heparan Sulfate Sulfotransferases in Zebrafish: Ii. The 6-o-sulfotransferase Family.. Dev. Dyn. Dec 2006;235:3432-7
Abstract
Heparan sulfate (HS) is an unbranched chain of repetitive disaccharides, which specifically binds ligands when attached to the cell surface or secreted extracellularly. HS chains contain sulfated domains termed the HS fine structure, which gives HS specific binding affinities for extracellular ligands. HS 6-O-sulfotransferases (6-OST) catalyze the transfer of sulfate groups to the 6-O position of glucosamine residues of HS. We report here the characterization and developmental expression analysis of the 6-OST gene family in the zebrafish. The zebrafish 6-OST gene family consists of four conserved vertebrate orthologues, including a gene duplication specific to zebrafish. We examined the mRNA expression patterns in several tissues/organs throughout early zebrafish development, including early cleavage stages, eyes, somites, brain, internal organ primordial, and pectoral fin development. Members of the 6-OST gene family have spatially and temporally distinct restricted expression, suggesting in vivo functional differences exist between members of this family.
Mesh Headings (Keywords): Amino Acid Sequence, Animals, Cloning, Molecular, Gene Expression Regulation, Developmental, Gene Expression Regulation, Enzymologic, In Situ Hybridization, Molecular Sequence Data, Multigene Family, Phylogeny, RNA, Messenger, Sequence Homology, Amino Acid, Sulfotransferases, Zebrafish, Zebrafish Proteins
Check for Full Text / PubMed Unique Identifier (PMID): 17075883
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