A Novel Index of Insulin Resistance Determined from the Homeostasis Model Assessment Index and Adiponectin Levels in Japanese Subjects.
From: Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, 2-2 Yamadaoka, Suita City, Japan. matuhisa@medone.med.osaka-u.ac.jp
Diabetes research and clinical practice
- Publish Date: Jul 2007
- ISSN: 0168-8227
- Volume: 77
- Issue: 1
- Pages: 151-4
- Medium: Print
- Language: English
- Citation (JAMA): Matsuhisa Munehide, Yamasaki Yoshimitsu, Emoto Masanori, et al. A Novel Index of Insulin Resistance Determined from the Homeostasis Model Assessment Index and Adiponectin Levels in Japanese Subjects.. Diabetes Res. Clin. Pract. Jul 2007;77:151-4
Abstract
Insulin resistance is the principal cause of glucose intolerance and type 2 diabetes and induces progression of severe atherosclerosis in these patients. Adiponectin, the adipose-specific proteins, is known to correlate negatively with insulin resistance in patients with obesity and type 2 diabetes. The purpose of this study was to evaluate the potential of using serum adiponectin levels as a marker of insulin resistance in various states of insulin resistance. Furthermore, we attempted to establish a modified index of the homeostasis model assessment index (HOMA-IR), calculated from the product of serum insulin and plasma glucose levels divided by serum adiponectin levels (HOMA-AD). We recruited 117 Japanese subjects with various degrees of glucose tolerance and determined serum adiponectin levels and insulin sensitivity (M-value) by using the euglycemic hyperinsulinemic clamp technique. M-value, the gold standard index of insulin resistance, correlates significantly and independently with fasting insulin (r=-0.313, P<0.001), glucose (r=-0.319, P<0.001), and adiponectin (r=0.241, P<0.002) levels. M-values were more significantly correlated with HOMA-AD (r=-0.643, P<0.001) than HOMA-IR values (r=-0.591, P<0.001). In subjects with moderate hyperglycemia (fasting glucose levels>8.0mmol/L, n=30), HOMA-AD showed a more significant correlation with the M-value than HOMA-IR (r=-0.535, P=0.005 versus r=-0.461, P=0.010). We would therefore like to propose a novel index, HOMA-AD, as a simple and adequate index for determining insulin resistance even in diabetic patients with overt hyperglycemia.
Mesh Headings (Keywords): Adiponectin, Adult, Blood Glucose, Diabetes Mellitus, Type 2, Fasting, Glucose Clamp Technique, Homeostasis, Humans, Insulin Resistance, Japan, Middle Aged, Models, Biological, Predictive Value of Tests
Check for Full Text / PubMed Unique Identifier (PMID): 17081646
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