Nucleic Acid-sensing Tlrs As Modifiers of Autoimmunity.
From: Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
Journal of immunology (Baltimore, Md. : 1950)
- Publish Date: Nov 2006
- ISSN: 0022-1767
- Volume: 177
- Issue: 10
- Pages: 6573-8
- Medium: Print
- Language: English
- Citation (JAMA): Deane Jonathan A, Bolland Silvia, et al. Nucleic Acid-sensing Tlrs As Modifiers of Autoimmunity.. J. Immunol. Nov 2006;177:6573-8
Abstract
The immune system requires precise regulation of activating and inhibitory signals so that it can mount effective responses against pathogens while ensuring tolerance to self-components. Some of the most potent activation signals are triggered by innate immune molecules, particularly those in the TLR family. Recent studies have shown that engagement of TLRs plays a significant role in both innate and adaptive immunity. This review focuses on the ways that TLR function might contribute to the etiology of lupus-like syndromes in the context of an autoimmune-prone environment. By considering the sources, localization, and expression of both nucleic acids and the molecules that bind them, we discuss several ways that innate immunity can play a role in the development of systemic autoimmunity.
Mesh Headings (Keywords): Animals, Autoimmune Diseases, DNA, Humans, Immunity, Natural, RNA, Toll-Like Receptors
Check for Full Text / PubMed Unique Identifier (PMID): 17082566
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