Cutting Edge: the Phosphoinositide 3-kinase P110 Delta is Critical for the Function of Cd4+cd25+foxp3+ Regulatory T Cells.
From: Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom.
Journal of immunology (Baltimore, Md. : 1950)
- Publish Date: Nov 2006
- ISSN: 0022-1767
- Volume: 177
- Issue: 10
- Pages: 6598-602
- Medium: Print
- Language: English
- Citation (JAMA): Patton Daniel T, Garden Oliver A, Pearce Wayne P, et al. Cutting Edge: the Phosphoinositide 3-kinase P110 Delta is Critical for the Function of Cd4+cd25+foxp3+ Regulatory T Cells.. J. Immunol. Nov 2006;177:6598-602
Abstract
CD4+CD25+Foxp3+ regulatory T cells (Tregs) contribute to the maintenance of peripheral tolerance by inhibiting the expansion and function of conventional T cells. Treg development and homeostasis are regulated by the Ag receptor, costimulatory receptors such as CD28 and CTLA-4, and cytokines such as IL-2, IL-10, and TGF-beta. Here we show that the proportions of Tregs in the spleen and lymph nodes of mice with inactive p110delta PI3K (p110deltaD910A/D910A) are reduced despite enhanced Treg selection in the thymus. p110deltaD910A/D910A CD4+CD25+Foxp3+ Tregs showed attenuated suppressor function in vitro and failed to secrete IL-10. In adoptive transfer experiments, p110deltaD910A/D910A T cells failed to protect against experimental colitis. The identification of p110delta as an intracellular signaling protein that regulates the activity of CD4+CD25+Foxp3+ Tregs may facilitate the further elucidation of the molecular mechanisms responsible for Treg-mediated suppression.
Mesh Headings (Keywords): 1-Phosphatidylinositol 3-Kinase, Animals, Catalytic Domain, Cell Differentiation, Cell Proliferation, Cells, Cultured, Coculture Techniques, Forkhead Transcription Factors, Growth Inhibitors, Inflammation, Interleukin-10, Interleukin-2, Interleukin-2 Receptor alpha Subunit, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Mice, Mutant Strains, T-Lymphocytes, Regulatory
Check for Full Text / PubMed Unique Identifier (PMID): 17082571
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