Isolation and Characterization of the First American Bottlenose Dolphin Papillomavirus: Tursiops Truncatus Papillomavirus Type 2.
From: Harbor Branch Oceanographic Institution, Division of Marine Mammal Research and Conservation, 5600 US 1 North, Fort Pierce, FL 34946, USA. Manuela.Rehtanz@gmx.de
The Journal of general virology
- Publish Date: Dec 2006
- ISSN: 0022-1317
- Volume: 87
- Issue: Pt 12
- Pages: 3559-65
- Medium: Print
- Language: English
- Citation (JAMA): Rehtanz Manuela, Ghim Shin-Je, Rector Annabel, et al. Isolation and Characterization of the First American Bottlenose Dolphin Papillomavirus: Tursiops Truncatus Papillomavirus Type 2.. J. Gen. Virol. Dec 2006;87:3559-65
Abstract
A novel papillomavirus (PV) was isolated from a genital condyloma of a free-ranging bottlenose dolphin inhabiting the coastal waters of Charleston Harbor, SC, USA: Tursiops truncatus papillomavirus type 2 (TtPV2). This novel virus represents the first isolated North American cetacean PV and the first American bottlenose dolphin PV. After the viral genome was cloned, sequenced and characterized genetically, phylogenetic analyses revealed that TtPV2 is most similar to the only published cetacean PV isolated and characterized thus far, Phocoena spinipinnis PV type 1 (PsPV1). A striking feature of the genome of TtPV2, as well as that of PsPV1, is the lack of an E7 open reading frame, which typically encodes one of the oncogenic proteins believed to be responsible for malignant transformation in the high-risk mucosotropic human papillomaviruses (HPVs). TtPV2 E6 contains a PDZ-binding motif that has been shown to be involved in transformation in the case of high-risk genital HPVs.
Mesh Headings (Keywords): Amino Acid Motifs, Animals, Bottle-Nosed Dolphin, Cloning, Molecular, Condylomata Acuminata, DNA, Viral, Genome, Viral, Molecular Sequence Data, Papillomaviridae, Papillomavirus E7 Proteins, Papillomavirus Infections, Phylogeny, Sequence Analysis, DNA, Sequence Homology, United States, Viral Proteins
Check for Full Text / PubMed Unique Identifier (PMID): 17098971
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