Peri-response Pharmacokinetics of Remifentanil During a Self-administration Session Indicates That Neither Blood nor Brain Levels Are Titrated.
From: Division of Neurochemistry, Department of Psychiatry, Medical University Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.
Annals of the New York Academy of Sciences
- Publish Date: Aug 2006
- ISSN: 0077-8923
- Volume: 1074
- Issue:
- Pages: 497-504
- Medium: Print
- Language: English
- Citation (JAMA): Crespo Jose A, Panlilio Leigh V, Schindler Charles W, et al. Peri-response Pharmacokinetics of Remifentanil During a Self-administration Session Indicates That Neither Blood nor Brain Levels Are Titrated.. Ann. N. Y. Acad. Sci. Aug 2006;1074:497-504
Abstract
An individual’s drug abuse pattern is determined by a multitude of factors. Among these, simple pharmacological determinants of within-binge drug consumption are sorely underinvestigated. We therefore determined if within-session operant responsing to the ultra-short-acting mu opioid agonist remifentanil (RMF) was determined by blood or brain RMF levels or changes thereof. Our peri-response analysis did not detect any “threshold” RMF level, either in blood or in the nucleus accumbens (NAc) core as a deep brain region that might determine a rat’s “decision” to re-emit a response during a multiple-injection drug self-administration session. The peri-response analysis also failed to find any peak RMF level, either in blood or in the NAc core, which could serve as a “ceiling” level. Thus, our findings strongly suggest that titration of blood or brain RMF levels does not determine a rat’s intra-session operant response.
Mesh Headings (Keywords): Animals, Brain, Nucleus Accumbens, Piperidines, Rats, Self Administration, Time Factors
Check for Full Text / PubMed Unique Identifier (PMID): 17105948
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