Hepatic Lipid Metabolism Changes in Short- and Long-term Prehepatic Portal Hypertensive Rats.
From: Surgery I Department, School of Medicine, Complutense University of Madrid, Spain. maaller@med.ucm.es
World journal of gastroenterology : WJG
- Publish Date: Nov 2006
- ISSN: 1007-9327
- Volume: 12
- Issue: 42
- Pages: 6828-34
- Medium: Print
- Language: English
- Citation (JAMA): Aller Maria-Angeles, Vara Elena, García Cruz, et al. Hepatic Lipid Metabolism Changes in Short- and Long-term Prehepatic Portal Hypertensive Rats.. World J. Gastroenterol. Nov 2006;12:6828-34
Abstract
AIM: To verify the impairment of the hepatic lipid metabolism in prehepatic portal hypertension. METHODS: The concentrations of free fatty acids, diacylglycerol, triglycerides, and phospholipids were assayed by using D-[U-14C] glucose incorporation in the different lipid fractions and thin-layer chromatography and cholesterol was measured by spectrophotometry, in liver samples of Wistar rats with partial portal vein ligation at short- (1 mo) and long-term (1 year) (i.e. portal hypertensive rats) and the control rats. RESULTS: In the portal hypertensive rats, liver phospholipid synthesis significantly decreased (7.42 +/- 0.50 vs 4.70 +/- 0.44 nCi/g protein; P < 0.01) and was associated with an increased synthesis of free fatty acids (2.08 +/- 0.14 vs 3.36 +/- 0.33 nCi/g protein; P < 0.05), diacylglycerol (1.93 +/- 0.2 vs 2.26 +/- 0.28 nCi/g protein), triglycerides (2.40 +/- 0.30 vs 4.49 +/- 0.15 nCi/g protein) and cholesterol (24.28 +/- 2.12 vs 57.66 +/- 3.26 mg/g protein; P < 0.01). CONCLUSION: Prehepatic portal hypertension in rats impairs the liver lipid metabolism. This impairment consists in an increase in lipid deposits (triglycerides, diacylglycerol and cholesterol) in the liver, accompanied by a decrease in phospholipid synthesis.
Mesh Headings (Keywords): Animals, Blood Pressure, Body Weight, Cholesterol, Fatty Acids, Nonesterified, Hypertension, Portal, Lipid Metabolism, Liver, Liver Circulation, Male, Organ Size, Phospholipids, Portal Vein, Rats, Rats, Wistar, Time Factors, Triglycerides
Check for Full Text / PubMed Unique Identifier (PMID): 17106932
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.