The Prevention of Peritoneal Adhesions by in Situ Cross-linking Hydrogels of Hyaluronic Acid and Cellulose Derivatives.
From: Department of Chemical Engineering, Massachusetts Institute of Technology, 45 Carleton St., Cambridge, MA 02142, USA.
Biomaterials
- Publish Date: Feb 2007
- ISSN: 0142-9612
- Volume: 28
- Issue: 6
- Pages: 975-83
- Medium: Print
- Language: English
- Citation (JAMA): Ito Taichi, Yeo Yoon, Highley Christopher B, et al. The Prevention of Peritoneal Adhesions by in Situ Cross-linking Hydrogels of Hyaluronic Acid and Cellulose Derivatives.. Biomaterials Feb 2007;28:975-83
Abstract
Post-operative peritoneal adhesions can cause pelvic pain, infertility, and potentially lethal bowel obstruction. We have designed and synthesized injectable hydrogels that are formed by mixing hydrazide-modified hyaluronic acid (HA) with aldehyde-modified versions of cellulose derivatives such as carboxymethylcellulose (CMC), hydroxypropylmethylcellulose (HPMC), and methylcellulose (MC). Gelation of these hydrogels occurred in less than 1 min, and had higher shear moduli than that of HA-HA gel (HAX). Hydrogels degraded in the presence of hyaluronidase in vitro, with HA-MC and HA-HPMC degrading more slowly than HAX and HA-CMC. The aldehyde-modified cellulose derivatives showed dose-dependent mild-to-moderate cytotoxicity to mesothelial cells and macrophages in vitro, but all were biocompatible in the murine peritoneum, causing no adhesions for 3 weeks. All the cellulose-derived gels showed efficacy in reducing the area of adhesion formation in a rabbit sidewall defect-bowel abrasion model.
Mesh Headings (Keywords): Adhesions, Animals, Biocompatible Materials, Cellulose, Cross-Linking Reagents, Hyaluronic Acid, Hydrogels, Materials Testing, Mice, Peritoneal Diseases, Peritoneum, Rabbits
Check for Full Text / PubMed Unique Identifier (PMID): 17109954
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