Vagal Afferents Mediate the Feeding Response to Mercaptoacetate but Not to the Beta (3) Adrenergic Receptor Agonist Cl 316,243.
From: Institute of Animal Sciences, ETH Zurich, Schorenstrasse 16, CH-8603 Schwerzenbach, Switzerland.
Neuroscience letters
- Publish Date: Jan 2007
- ISSN: 0304-3940
- Volume: 411
- Issue: 2
- Pages: 104-7
- Medium: Print
- Language: English
- Citation (JAMA): Brandt Karsten, Arnold Myrtha, Geary Nori, et al. Vagal Afferents Mediate the Feeding Response to Mercaptoacetate but Not to the Beta (3) Adrenergic Receptor Agonist Cl 316,243.. Neurosci. Lett. Jan 2007;411:104-7
Abstract
To evaluate the role of subdiaphragmatic vagal afferents in the anorectic response to peripheral administration of the highly selective beta(3)-adrenergic receptor agonist CL 316,243 (CL), we tested the ability of intraperitoneal (IP) injections of CL to inhibit feeding in rats with subdiaphragmatic vagal deafferentation (SDA, n=13) or sham surgeries (SHAM, n=13). Doses of 10, 100 and 1000 ng/kg CL significantly reduced feeding by statistically similar amounts in SHAM and SDA rats. One hour after IP injection, each dose of CL also significantly increased plasma concentrations of free fatty acids and beta-hydroxybutyrate, an indicator of hepatic fatty acid oxidation (FAO), whereas 6h after injection only the two highest CL doses increased plasma beta-hydroxybutyrate. In contrast, peripheral administration of the FAO inhibitor mercaptoacetate (MA, 45.6 mg/kg IP) stimulated feeding in SHAM but not in SDA rats, extending previous data suggesting a necessary role of vagal afferents in the feeding-stimulatory effect of FAO inhibition. We conclude that subdiaphragmatic vagal afferents are essential for the feeding-stimulatory action of MA but not for the anorectic action of peripheral CL and that CL-induced increase in hepatic FAO is not essential for its feeding-inhibitory effect.
Mesh Headings (Keywords): 3-Hydroxybutyric Acid, Adrenergic beta-Agonists, Afferent Pathways, Analysis of Variance, Animals, Behavior, Animal, Dioxoles, Dose-Response Relationship, Drug, Eating, Fatty Acids, Food Deprivation, Male, Rats, Rats, Sprague-Dawley, Thioglycolates, Time Factors, Vagotomy, Vagus Nerve
Check for Full Text / PubMed Unique Identifier (PMID): 17112664
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