Glutathione Availability Modulates Alveolar Macrophage Function in the Chronic Ethanol-fed Rat.
From: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. lbrow03@emory.edu
American journal of physiology. Lung cellular and molecular physiology
- Publish Date: Apr 2007
- ISSN: 1040-0605
- Volume: 292
- Issue: 4
- Pages: L824-32
- Medium: Print
- Language: English
- Citation (JAMA): Brown Lou Ann S, Ping Xiao-Du, Harris Frank L, et al. Glutathione Availability Modulates Alveolar Macrophage Function in the Chronic Ethanol-fed Rat.. Am. J. Physiol. Lung Cell Mol. Physiol. Apr 2007;292:L824-32
Abstract
We have previously demonstrated that chronic alcohol exposure decreases glutathione in the alveolar space. Although alcohol use is associated with decreased alveolar macrophage function, the mechanism by which alcohol impairs macrophage phagocytosis is unknown. In the current study, we examined the possibility that ethanol-induced alveolar macrophage dysfunction was secondary to decreased glutathione and subsequent chronic oxidative stress in the alveolar space. After 6 wk of ethanol ingestion, oxidant stress in the alveolar macrophages was evidenced by a 30-mV oxidation of the GSH/GSSG redox potential (P
Mesh Headings (Keywords): Alcoholism, Animals, Apoptosis, Cell Survival, Cells, Cultured, Glutathione, Homeostasis, In Situ Nick-End Labeling, Macrophages, Alveolar, Male, Microscopy, Confocal, Oxidative Stress, Phagocytosis, Poly(ADP-ribose) Polymerases, Rats, Rats, Sprague-Dawley
Check for Full Text / PubMed Unique Identifier (PMID): 17122355
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.