Firedb--a Database of Functionally Important Residues from Proteins of Known Structure.
From: Computational and Structural Biology Program, Spanish National Cancer Research Centre (CNIO) Melchor Fernández Almagro, 3, E-28029, Madrid, Spain. glopez@cnio.es
Nucleic acids research
- Publish Date: Jan 2007
- ISSN: 1362-4962
- Volume: 35
- Issue: Database issue
- Pages: D219-23
- Medium: Internet
- Language: English
- Citation (JAMA): Lopez Gonzalo, Valencia A, Tress M, et al. Firedb--a Database of Functionally Important Residues from Proteins of Known Structure.. Nucleic Acids Res. Jan 2007;35:D219-23
Abstract
The FireDB database is a databank for functional information relating to proteins with known structures. It contains the most comprehensive and detailed repository of known functionally important residues, bringing together both ligand binding and catalytic residues in one site. The platform integrates biologically relevant data filtered from the close atomic contacts in Protein Data Bank crystal structures and reliably annotated catalytic residues from the Catalytic Site Atlas. The interface allows users to make queries by protein, ligand or keyword. Relevant biologically important residues are displayed in a simple and easy to read manner that allows users to assess binding site similarity across homologous proteins. Binding site residue variations can also be viewed with molecular visualization tools. The database is available at http://firedb.bioinfo.cnio.es.
Mesh Headings (Keywords): Amino Acids, Binding Sites, Catalytic Domain, Databases, Protein, Internet, Ligands, Models, Molecular, Protein Conformation, Proteins, Tacrolimus Binding Proteins, User-Computer Interface
Check for Full Text / PubMed Unique Identifier (PMID): 17132832
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