Sustained Beneficial Metabolic Effects 18 Months After a 30-day Very Low Calorie Diet in Severely Obese, Insulin-treated Patients with Type 2 Diabetes.
From: Department of General Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands. i.m.jazet@lumc.nl
Diabetes research and clinical practice
- Publish Date: Jul 2007
- ISSN: 0168-8227
- Volume: 77
- Issue: 1
- Pages: 70-6
- Medium: Print
- Language: English
- Citation (JAMA): Jazet Ingrid M, de Craen Anton J, van Schie Eveline M, et al. Sustained Beneficial Metabolic Effects 18 Months After a 30-day Very Low Calorie Diet in Severely Obese, Insulin-treated Patients with Type 2 Diabetes.. Diabetes Res. Clin. Pract. Jul 2007;77:70-6
Abstract
Eighteen insulin-treated obese type 2 diabetic patients were followed for 18 months after they followed a 30-day very low calorie diet (VLCD, 450kCal/day) with the cessation of all glucose-lowering medication. After the 30-day VLCD, caloric intake was slowly increased to eucaloric and glucose-lowering medication was restarted if necessary. On day 0 and 30 of the VLCD and after 18 months follow-up, bodyweight, blood-pressure, glycaemic control and lipid levels were measured. The 30-day VLCD significantly reduced bodyweight (-11.7+/-0.7kg, mean+/-S.E.M.) and improved dyslipidaemia, hypertension and glycaemia. As a group, this effect was sustained at 18 months follow-up despite the fact that patients used less lipid-, blood-pressure- and glucose-lowering medication. Especially, the use of insulin was significantly reduced: 18 out of 18 patients on day 0 (mean 137+/-22units/day); 5 out of 18 patients at 18 months (86+/-14units/day). Patients using insulin at 18 months had regained weight to prediet levels, but still had a better cardiovascular risk profile compared with before the dietary intervention. Thus, a once-only 30-day VLCD leads to a sustained improvement in glycaemia, dyslipidaemia and blood-pressure up to 18 months follow-up in obese type 2 diabetic patients, even, although to a lesser extent, in patients who regained body-weight.
Mesh Headings (Keywords): Blood Glucose, Blood Pressure, Caloric Restriction, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Obesity, Morbid
Check for Full Text / PubMed Unique Identifier (PMID): 17134786
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