Gammadelta T Cells Promote Anterior Chamber-associated Immune Deviation and Immune Privilege Through Their Production of Il-10.
From: Immunology Graduate Program, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Journal of immunology (Baltimore, Md. : 1950)
- Publish Date: Dec 2006
- ISSN: 0022-1767
- Volume: 177
- Issue: 12
- Pages: 8331-7
- Medium: Print
- Language: English
- Citation (JAMA): Ashour Hossam M, Niederkorn Jerry Y, et al. Gammadelta T Cells Promote Anterior Chamber-associated Immune Deviation and Immune Privilege Through Their Production of Il-10.. J. Immunol. Dec 2006;177:8331-7
Abstract
Anterior chamber-associated immune deviation (ACAID) is a form of peripheral tolerance that is induced by introducing Ags into the anterior chamber (AC) of the eye, and is maintained by Ag-specific regulatory T cells (Tregs). ACAID regulates harmful immune responses that can lead to irreparable injury to innocent bystander cells that are incapable of regeneration. This form of immune privilege in the eye is mediated through Tregs and is a product of complex cellular interactions. These involve F4/80+ ocular APCs, B cells, NKT cells, CD4+CD25+ Tregs, and CD8+ Tregs. gammadelta T cells are crucial for the generation of ACAID and for corneal allograft survival. However, the functions of gammadelta T cells in ACAID are unknown. Several hypotheses were proposed for determining the functions of gammadelta T cells in ACAID. The results indicate that gammadelta T cells do not cause direct suppression of delayed-type hypersensitivity nor do they act as tolerogenic APCs. In contrast, gammadelta T cells were shown to secrete IL-10 and facilitate the generation of ACAID Tregs. Moreover, the contribution of gammadelta T cells ACAID generation could be replaced by adding exogenous recombinant mouse IL-10 to ACAID spleen cell cultures lacking gammadelta T cells.
Mesh Headings (Keywords): Animals, Anterior Chamber, Antigen-Presenting Cells, Cell Communication, Immune Tolerance, Interleukin-10, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Antigen, T-Cell, gamma-delta, T-Lymphocytes, Regulatory
Check for Full Text / PubMed Unique Identifier (PMID): 17142729
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