Persister Cells, Dormancy and Infectious Disease.
From: Antimicrobial Discovery Center, Department of Biology, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, USA. k.lewis@neu.edu
Nature reviews. Microbiology
- Publish Date: Jan 2007
- ISSN: 1740-1534
- Volume: 5
- Issue: 1
- Pages: 48-56
- Medium: Internet
- Language: English
- Citation (JAMA): Lewis Kim, et al. Persister Cells, Dormancy and Infectious Disease.. Nat. Rev. Microbiol. Jan 2007;5:48-56
Abstract
Several well-recognized puzzles in microbiology have remained unsolved for decades. These include latent bacterial infections, unculturable microorganisms, persister cells and biofilm multidrug tolerance. Accumulating evidence suggests that these seemingly disparate phenomena result from the ability of bacteria to enter into a dormant (non-dividing) state. The molecular mechanisms that underlie the formation of dormant persister cells are now being unravelled and are the focus of this Review.
Mesh Headings (Keywords): Adaptation, Physiological, Anti-Bacterial Agents, Bacteria, Bacterial Infections, Bacterial Physiology, Biofilms, Drug Resistance, Multiple, Bacterial, Drug Tolerance, Gene Expression Regulation, Bacterial, Genes, Bacterial, Humans, Microbial Viability
Check for Full Text / PubMed Unique Identifier (PMID): 17143318
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