Cpg Oligonucleotides Improve the Protective Immune Response Induced by the Licensed Anthrax Vaccine.
From: Section of Retroviral Immunology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. Klinman@CBER.FDA.GOV
Annals of the New York Academy of Sciences
- Publish Date: Oct 2006
- ISSN: 0077-8923
- Volume: 1082
- Issue:
- Pages: 137-50
- Medium: Print
- Language: English
- Citation (JAMA): Klinman Dennis M, Xie Hang, Ivins Bruce E, et al. Cpg Oligonucleotides Improve the Protective Immune Response Induced by the Licensed Anthrax Vaccine.. Ann. N. Y. Acad. Sci. Oct 2006;1082:137-50
Abstract
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants, improving the response elicited by a coadministered vaccine. Combining CpG ODN with anthrax vaccine adsorbed (AVA, the licensed human vaccine) increases the speed, magnitude, and avidity of the resultant antibody response. IgG Abs against anthrax protective antigen (PA) protect mice, guinuea pigs, and rhesus macaques from infection.
Mesh Headings (Keywords): Adjuvants, Immunologic, Animals, Anthrax Vaccines, Antibody Formation, Antigens, Bacterial, Antigens, Viral, Bacterial Toxins, CpG Islands, Guinea Pigs, Humans, Immunoglobulin G, Macaca mulatta, Mice, Oligodeoxyribonucleotides
Check for Full Text / PubMed Unique Identifier (PMID): 17145935
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