E-cadherin Repression Contributes to C-myc-induced Epithelial Cell Transformation.
From: Department of Pharmacology, Dartmouth Medical School, Norris Cotton Cancer Center, Lebanon, NH 03756, USA.
Oncogene
- Publish Date: May 2007
- ISSN: 0950-9232
- Volume: 26
- Issue: 24
- Pages: 3582-6
- Medium: Print
- Language: English
- Citation (JAMA): Cowling V H, Cole M D, et al. E-cadherin Repression Contributes to C-myc-induced Epithelial Cell Transformation.. Oncogene May 2007;26:3582-6
Abstract
c-Myc oncoprotein is overexpressed in a significant proportion of human epithelial cancers, and experimental overexpression of c-Myc in epithelial cells promotes tumour formation. However, it is not known how c-Myc promotes epithelial cell tumour formation. We report that c-Myc expression in human mammary epithelial cells induces a dramatic change in cell morphology, with some characteristics of an ‘epithelial to mesenchymal transition’. E-cadherin expression is repressed by a post-transcriptional mechanism in cells expressing c-Myc. Furthermore, E-cadherin repression is necessary for c-Myc-induced cell transformation.
Mesh Headings (Keywords): Breast Neoplasms, Cadherins, Cell Transformation, Neoplastic, Cells, Cultured, Epithelial Cells, Gene Expression Regulation, Neoplastic, Humans, Mammary Glands, Human, Proto-Oncogene Proteins c-myc
Check for Full Text / PubMed Unique Identifier (PMID): 17146437
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