Myoblast Fusion in Drosophila Melanogaster is Mediated Through a Fusion-restricted Myogenic-adhesive Structure (Furmas).
From: Philipps-Universität Marburg, Fachbereich Biologie, Entwicklungsbiologie, Marburg, Germany.
Developmental dynamics : an official publication of the American Association of Anatomists
- Publish Date: Feb 2007
- ISSN: 1058-8388
- Volume: 236
- Issue: 2
- Pages: 404-15
- Medium: Print
- Language: English
- Citation (JAMA): Kesper Dörthe Andrea, Stute Christiana, Buttgereit Detlev, et al. Myoblast Fusion in Drosophila Melanogaster is Mediated Through a Fusion-restricted Myogenic-adhesive Structure (Furmas).. Dev. Dyn. Feb 2007;236:404-15
Abstract
During myogenesis in Drosophila embryos, a prominent adhesive structure is formed between precursor cells and fusion-competent myoblasts (fcms). Here, we show that Duf/Kirre and its interaction partners Rols7 (found in founder myoblasts and growing myotubes) and Sns (found in fcms) are organized in a ring-structure at the contact points of fcms with precursor cells, while cytoskeletal components like F-actin and Titin are centered in this ring in both cell types. The cytoplasmic protein Blow colocalizes with the actin plugs in fcms after cell adhesion. Furthermore, the requirement of additional as yet unidentified components was demonstrated by using mammalian C2C12 myoblasts. In this study, we propose that the fusion-restricted myogenic-adhesive structure (FuRMAS) is pivotal in linking cell adhesion as well as local F-actin assembly and dynamics to downstream events that ultimately lead to plasma membrane fusion. Moreover, we suggest that the FuRMAS may restrict the area of membrane breakdown.
Mesh Headings (Keywords): Actins, Animals, Cell Adhesion, Cell Fusion, Cell Line, Drosophila Proteins, Drosophila melanogaster, Immunoglobulins, Immunohistochemistry, Membrane Proteins, Multiprotein Complexes, Muscle Proteins, Myoblasts
Check for Full Text / PubMed Unique Identifier (PMID): 17146786
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