Regulation of Appetite and Insulin Signaling in Inflammatory States.
From: Developmental Biology Section, Foundation for Biomedical Research of the Academy of Athens, Athens, 11527 Greece.
Annals of the New York Academy of Sciences
- Publish Date: Nov 2006
- ISSN: 0077-8923
- Volume: 1083
- Issue:
- Pages: 319-28
- Medium: Print
- Language: English
- Citation (JAMA): Teli Thalia, Xanthaki Despina, Karalis Katia P, et al. Regulation of Appetite and Insulin Signaling in Inflammatory States.. Ann. N. Y. Acad. Sci. Nov 2006;1083:319-28
Abstract
Inflammatory states are characterized by decreased food intake, hyperglycemia, and insulin resistance. The contribution of cytokines in this phenotype is important and is exerted through activation of SOCS proteins and inhibition of insulin signaling, as well as through direct stimulation of the ob gene. Obesity, a condition that has reached epidemic rates, is characterized by hyperglycemia, hyperlipidemia, insulin resistance and increased food intake, and body weight. In the following article we summarize the current views of the mechanisms underlying insulin resistance in obesity and the other inflammatory states. We also discuss the regulation of appetite in inflammatory states, and we provide evidence on the cytokine-independent induction of anorexia following immune activation in mice. Understanding of the exact mechanisms regulating these processes may provide important insights for the control of this group of diseases that compromise to a great extent the quality of life and are associated with high mortality.
Mesh Headings (Keywords): Animals, Appetite, Cytokines, Humans, Hyperglycemia, Inflammation, Insulin, Insulin Resistance, Mice, Obesity, Signal Transduction
Check for Full Text / PubMed Unique Identifier (PMID): 17148747
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