Electrodeposition of Anchored Polypyrrole Film on Microelectrodes and Stimulation of Cultured Cardiac Myocytes.
From: Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, Aramaki-Aoba 6-6-01, Sendai 980-8579, Japan. nishizawa@biomems.mech.tohoku.ac.jp
Biomaterials
- Publish Date: Mar 2007
- ISSN: 0142-9612
- Volume: 28
- Issue: 8
- Pages: 1480-5
- Medium: Print
- Language: English
- Citation (JAMA): Nishizawa Matsuhiko, Nozaki Hyuma, Kaji Hirokazu, et al. Electrodeposition of Anchored Polypyrrole Film on Microelectrodes and Stimulation of Cultured Cardiac Myocytes.. Biomaterials Mar 2007;28:1480-5
Abstract
The electrically conducting polymer polypyrrole (PPy) was electrochemically deposited onto Pt microelectrodes on a polyimide (PI) substrate. Pre-modification of the PI surface with a self-assembled monolayer of octadecyltrichlorosilane-induced anisotropic lateral growth of PPy along the PI surface and enhanced adhesive strength of the PPy film. The lateral growth of PPy film around the electrode anchored the whole film to the substrate. External stimulation of cultured cardiac myocytes was carried out using the PPy-coated microelectrode. The myocytes on the microelectrode substrate were electrically conjugated to form a sheet, and showed synchronized beating upon stimulation. The threshold charge for effective stimulation of a 0.8 cm(2) sheet of myocytes was around 0.2 microC, roughly corresponding to a membrane depolarization of 250 mV.
Mesh Headings (Keywords): Animals, Biocompatible Materials, Cells, Cultured, Chick Embryo, Electric Stimulation, Electroplating, Microelectrodes, Myocytes, Cardiac, Polymers, Pyrroles
Check for Full Text / PubMed Unique Identifier (PMID): 17166583
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.