Blockade of High Mobility Group Box-1 Protein Attenuates Experimental Severe Acute Pancreatitis.
From: Department of Gastroenterological Surgery, Kobe University Graduate School of Medical Sciences, Kobe 650-0017, Japan. hdhrsawa@med.kobe-u.ac.jp
World journal of gastroenterology : WJG
- Publish Date: Dec 2006
- ISSN: 1007-9327
- Volume: 12
- Issue: 47
- Pages: 7666-70
- Medium: Print
- Language: English
- Citation (JAMA): Sawa Hidehiro, Ueda Takashi, Takeyama Yoshifumi, et al. Blockade of High Mobility Group Box-1 Protein Attenuates Experimental Severe Acute Pancreatitis.. World J. Gastroenterol. Dec 2006;12:7666-70
Abstract
AIM: To examine the effects of anti-high mobility group box 1 (HMGB1) neutralizing antibody in experimental severe acute pancreatitis (SAP). METHODS: SAP was induced by creating closed duodenal loop in C3H/HeN mice. SAP was induced immediately after intraperitoneal injection of anti-HMGB1 neutralizing antibody (200 microg). Severity of pancreatitis, organ injury (liver, kidney and lung), and bacterial translocation to pancreas was examined 12 h after induction of SAP. RESULTS: Anti-HMGB1 neutralizing antibody significantly improved the elevation of the serum amylase level and the histological alterations of pancreas and lung in SAP. Anti-HMGB1 antibody also significantly ameliorated the elevations of serum alanine aminotransferase and creatinine in SAP. However, anti-HMGB1 antibody worsened the bacterial translocation to pancreas. CONCLUSION: Blockade of HMGB1 attenuated the development of SAP and associated organ dysfunction, suggesting that HMGB1 may act as a key mediator for inflammatory response and organ injury in SAP.
Mesh Headings (Keywords): Animals, Antibodies, Female, HMGB1 Protein, Immunotherapy, Mice, Mice, Inbred C3H, Pancreatitis, Severity of Illness Index
Check for Full Text / PubMed Unique Identifier (PMID): 17171797
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