Considerations for Target Validation and Industrial Approaches.
From: Global External Research and Development, Lilly Research Laboratories, Lilly Corporate Centre, Indianapolis, IN, USA.
Methods in molecular biology (Clifton, N.J.)
- Publish Date: 2007
- ISSN: 1064-3745
- Volume: 361
- Issue:
- Pages: 299-309
- Medium: Print
- Language: English
- Citation (JAMA): Plata-Salamán Carlos R, Ilyin Sergey E, et al. Considerations for Target Validation and Industrial Approaches.. Methods Mol. Biol. 2007;361:299-309
Abstract
Target validation in health and disease integrates the modulation of a certain molecular target with an expected biological/biochemical/physiological or pathophysiological response or effect. The current state-of-the-art in target validation requires the interface of multiple complementary approaches and technologies to define the mechanistic connectivity between a molecular target and underlying micro- and macrobiotic processes. Target validation also represents the basis for “drug target validation” with focus on therapeutic applications. The concepts of “target validation” and “drug-based therapeutic intervention” continue to coevolve as new classes of therapeutic agents and delivery systems emerge and enable us to target or modulate previously inaccessible molecular entities.
Mesh Headings (Keywords): Animals, Drug Design, Drug Evaluation, Preclinical, Proteomics, Technology, Pharmaceutical
Check for Full Text / PubMed Unique Identifier (PMID): 17172719
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