Interleukin-10 [Ata] Promoter Haplotype and Prostate Cancer Risk: a Population-based Study.
From: Department of Therapeutic Radiology and Oncology, Medical University of Graz, Auenbruggerplatz 32, 8036 Graz, Austria. tanja.eder@klinikum-graz.at
European journal of cancer (Oxford, England : 1990)
- Publish Date: Feb 2007
- ISSN: 0959-8049
- Volume: 43
- Issue: 3
- Pages: 472-5
- Medium: Print
- Language: English
- Citation (JAMA): Eder Tanja, Mayer Ramona, Langsenlehner Uwe, et al. Interleukin-10 [Ata] Promoter Haplotype and Prostate Cancer Risk: a Population-based Study.. Eur. J. Cancer Feb 2007;43:472-5
Abstract
Interleukin-10 (IL-10) is a multifunctional cytokine acting as inhibitor of inflammatory and immune responses as well as tumour induced angiogenesis. A common [ATA] haplotype formed by polymorphisms at positions -1082, -819 and -592in the promoter of the IL-10 gene is a strong determinant for IL-10 expression. The presence of this haplotype can be determined by analysis of the -592C>A polymorphism. To analyse the role of the IL-10 [ATA] haplotype in prostate cancer we performed a case-control study including 561 prostate cancer patients and 561 male, age-matched, control subjects without malignant disease. The IL-10 -592C>A polymorphism was determined by a 5’-nuclease assay (TaqMan). IL-10 -592 CC, CA and AA genotype frequencies were not significantly different between patients (53.6%, 40.0%, 6.4%) and controls (54.3%, 39.6%, 6.1%; p=0.96). IL-10 genotypes were furthermore not associated with tumour characteristics such as histological grade, T stage, PSA levels at diagnosis, or age at diagnosis. Therefore we conclude that the IL-10 -592C>A promoter polymorphism, tagging the IL-10 low-producer [ATA] haplotype, is not associated with risk for prostate cancer.
Mesh Headings (Keywords): Aged, Haplotypes, Humans, Interleukin-10, Male, Polymorphism, Genetic, Promoter Regions (Genetics), Prostatic Neoplasms, Risk Factors
Check for Full Text / PubMed Unique Identifier (PMID): 17182240
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.