Investigations into the in Vitro Antimicrobial Activity and Mode of Action of the Phenazine Antibiotic D-alanylgriseoluteic Acid.
From: Department of Plants Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK. stephen.giddens@plants.ox.ac.uk
International journal of antimicrobial agents
- Publish Date: Jan 2007
- ISSN: 0924-8579
- Volume: 29
- Issue: 1
- Pages: 93-7
- Medium: Print
- Language: English
- Citation (JAMA): Giddens Stephen R, Bean David C, et al. Investigations into the in Vitro Antimicrobial Activity and Mode of Action of the Phenazine Antibiotic D-alanylgriseoluteic Acid.. Int. J. Antimicrob. Agents Jan 2007;29:93-7
Abstract
D-Alanylgriseoluteic acid (AGA) is a potent antimicrobial phenazine compound produced by Pantoea agglomerans (Erwinia herbicola) Eh1087. Susceptibility tests against a range of microbes indicated that AGA had a broad spectrum of antimicrobial activity and was particularly active against Gram-positive pathogens. Comparison of the in vitro efficacy of AGA with eight other antibiotics against 119 clinical isolates of Streptococcus pneumoniae demonstrated that all were inhibited by low concentrations of AGA (minimal inhibitory concentration range
Mesh Headings (Keywords): Alanine, Anti-Bacterial Agents, Bacteria, Cytochromes c, DNA Damage, Drug Stability, Escherichia coli, Ferredoxin-NADP Reductase, Gene Expression Regulation, Bacterial, Gram-Negative Bacteria, Gram-Positive Bacteria, Microbial Sensitivity Tests, Molecular Structure, Mutagens, Oxidants, Oxidation-Reduction, Phenazines, SOS Response (Genetics), Streptococcus pneumoniae
Check for Full Text / PubMed Unique Identifier (PMID): 17189100
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