"Effect of Short-term Cigarette Smoking on Insulin Resistance and Lipid Profile in Asymptomatic Adults".
From: Department of Physiology, K.G. Medical University, Lucknow 226 003. vaniadhya@yahoomail.com
Indian journal of physiology and pharmacology
- Publish Date:
- ISSN: 0019-5499
- Volume: 50
- Issue: 3
- Pages: 285-90
- Medium: Print
- Language: English
- Citation (JAMA): Gupta Vani, Tiwari Sunita, Agarwal C G, et al. "Effect of Short-term Cigarette Smoking on Insulin Resistance and Lipid Profile in Asymptomatic Adults".. Indian J. Physiol. Pharmacol. ;50:285-90
Abstract
Present study examined the effect of short-term cigarette smoking on insulin resistance and lipid profile in asymptomatic healthy adults. This case control study comprised of 44 healthy male subjects in the age group of 18-40 yrs having BMI 25+3 and WHR < 1.0. Of these 22 smokers were included in the study group and 22 non-smokers in the control group. Subject selection was done such that one smoker and one non-smoker sibling or first degree male relative were selected from the same family. We compared fasting plasma glucose, insulin, lipid profile, and homeostatic model assessment index (HOMA Index) as a measure of insulin resistance between both the groups. Our observation showed that significantly higher values of serum glucose (133.36 +/- 23.45 mg/dl; P < 0.001), serum insulin (32.04 +/- 6.0 2 microU/ml; P < 0.001) and HOMA index (3.62 +/- 0.21; P < 0.001) were found in smokers as compared to non-smokers (serum glucose 86.95 +/- 19.32 mg/dl, insulin 20.09 +/- 4.8 microU/ml, HOMA index 3.29 +/- 0.30). No significant difference was observed for number of subjects having insulin resistance (HI > 3.8) and lipid profile in both the groups. Thus it appears that smokers are prone to develop hyperinsulenemia, hyperglycemia and the metabolic syndrome.
Mesh Headings (Keywords): Adolescent, Adult, Blood Glucose, Humans, Hyperglycemia, Insulin, Insulin Resistance, Lipids, Male, Smoking
Check for Full Text / PubMed Unique Identifier (PMID): 17193901
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