Effects of Kiom-79 on Hyperglycemia and Diabetic Nephropathy in Type 2 Diabetic Goto-kakizaki Rats.
From: Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, 461-24 Jeonmin-dong, Yuseong-gu, Daejeon 305-811, Republic of Korea.
Journal of ethnopharmacology
- Publish Date: May 2007
- ISSN: 0378-8741
- Volume: 111
- Issue: 2
- Pages: 240-7
- Medium: Print
- Language: English
- Citation (JAMA): Kim Chan-Sik, Sohn Eun Jin, Kim Young Sook, et al. Effects of Kiom-79 on Hyperglycemia and Diabetic Nephropathy in Type 2 Diabetic Goto-kakizaki Rats.. May 2007;111:240-7
Abstract
We investigated the effect of KIOM-79, 80% ethanolic extract of a new herbal prescription, on non-obese type 2 diabetic Goto-Kakizaki (GK) rats. The rats were treated orally with KIOM-79 (500 mg/kg body weight) once a day for 13 weeks to examine the long-term effects on hyperglycemia and glomerular histology as well as biochemical and functional abnormalities in kidney. As the results, we found that KIOM-79 reduced hyperglycemia (p<0.01), ameliorated insulin resistance (p<0.001), urinary protein excretion (p<0.01) and creatinine clearance (Ccr) (p<0.001), and inhibited glomerular AGE formation (p<0.001) in diabetic GK rats. We also found that KIOM-79 prevented the glomeruli enlargement, overexpression of type IV collagen (p<0.001), PKC protein (p<0.01), TGF-beta mRNA (p<0.05) and VEGF mRNA (p<0.05). Thus, based on our finding, KIOM-79 could reduce the hyperglycemia, and prevent or retard the development of diabetic nephropathy.
Mesh Headings (Keywords): Administration, Oral, Animals, Blood Glucose, Collagen Type IV, Creatine, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Drug Administration Schedule, Fasting, Glycosylation End Products, Advanced, Hypoglycemic Agents, Immunohistochemistry, Insulin, Insulin Resistance, Kidney Cortex, Male, Medicine, Herbal, Plant Extracts, Protein Kinase C, Proteinuria, RNA, Messenger, Rats, Rats, Inbred Strains, Transforming Growth Factor beta, Vascular Endothelial Growth Factor A
Check for Full Text / PubMed Unique Identifier (PMID): 17194556
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