Postnatal Lymphatic Partitioning from the Blood Vasculature in the Small Intestine Requires Fasting-induced Adipose Factor.
From: Center for Genome Sciences, Washington University School of Medicine, St. Louis, MO 63108, USA.
Proceedings of the National Academy of Sciences of the United States of America
- Publish Date: Jan 2007
- ISSN: 0027-8424
- Volume: 104
- Issue: 2
- Pages: 606-11
- Medium: Print
- Language: English
- Citation (JAMA): Bäckhed Fredrik, Crawford Peter A, O'Donnell David, et al. Postnatal Lymphatic Partitioning from the Blood Vasculature in the Small Intestine Requires Fasting-induced Adipose Factor.. Proc. Natl. Acad. Sci. U.S.A. Jan 2007;104:606-11
Abstract
Lymphatic vessels develop from specialized venous endothelial cells. Using knockout mice, we found that fasting-induced adipose factor (Fiaf) is required for functional partitioning of postnatal intestinal lymphatic and blood vessels. In wild-type animals, levels of intestinal Fiaf expression rise during the first postnatal day and peak at day 2, which coincides with the onset of the lymphatico-venous partitioning abnormality in Fiaf-/- mutants on a mixed 129/SvJ:C57BL/6 genetic background. Fiaf deficiency is not associated with disruption of the blood vasculature or with lymphatic endothelial recruitment of smooth muscle cells. We identified Prox1, a critical regulator of lymphangiogenesis, as a downstream target for Fiaf signaling in the intestinal lymphatic endothelium. This organ-specific lymphovascular abnormality can be rescued by allowing embryonic Fiaf-/- intestinal isografts to develop in Fiaf+/+ recipients.
Mesh Headings (Keywords): Animals, Animals, Newborn, Blood Proteins, Genes, Homeobox, Homeodomain Proteins, Intestine, Small, Lymphangiogenesis, Lymphatic Vessels, Mice, Mice, Knockout, Microcirculation, Transplantation, Isogeneic, Tumor Suppressor Proteins
Check for Full Text / PubMed Unique Identifier (PMID): 17202268
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