Non Invasive Evaluation of Liver Fibrosis in Paediatric Patients with Nonalcoholic Steatohepatitis.
From: Division of Gastroenterology, Hospital Casa Sollievo della Sofferenza, IRCCS, San Giovanni Rotondo, Italy.
World journal of gastroenterology : WJG
- Publish Date: Dec 2006
- ISSN: 1007-9327
- Volume: 12
- Issue: 48
- Pages: 7821-5
- Medium: Print
- Language: English
- Citation (JAMA): Iacobellis Angelo, Marcellini Matilde, Andriulli Angelo, et al. Non Invasive Evaluation of Liver Fibrosis in Paediatric Patients with Nonalcoholic Steatohepatitis.. World J. Gastroenterol. Dec 2006;12:7821-5
Abstract
AIM: To identify the independent predictors of hepatic fibrosis in 69 children with nonalcoholic steatohepatitis (NASH) due to nonalcoholic fatty liver disease (NAFLD). METHODS: All patients with clinically suspected NASH underwent liver biopsy as a confirmatory test. The following clinical and biochemical variables at baseline were examined as likely predictors of fibrosis at histology: age, body mass index (BMI), systolic blood pressure (SBP), dyastolic blood pressure (DBP), fasting glucose, fasting insulin, homeostatic model assessment for insulin resistence (HOMA-IR), cholesterol, tryglicerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ALT ratio, gamma glutamil transferase (GT), platelet count, prothrombin time (PT). RESULTS: At histology 28 (40.6%) patients had no fibrosis and 41 (59.4%) had mild to bridging fibrosis. At multivariate analysis, BMI > 26.3 was the only independent predictor of fibrosis (OR = 5.85, 95% CI = 1.6-21). CONCLUSION: BMI helps identify children with NASH who might have fibrotic deposition in the liver.
Mesh Headings (Keywords): Adolescent, Biopsy, Body Mass Index, Body Weight, Child, Disease Progression, Fatty Liver, Female, Glucose, Humans, Liver, Liver Cirrhosis, Male, Multivariate Analysis, Predictive Value of Tests, Risk Factors
Check for Full Text / PubMed Unique Identifier (PMID): 17203527
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.