A Circadian Sleep Disorder Reveals a Complex Clock.
From: Howard Hughes Medical Institute, Stanford University School of Medicine, 701-B Welch Road, Stanford, CA 94304, USA. mignot@stanford.edu
Cell
- Publish Date: Jan 2007
- ISSN: 0092-8674
- Volume: 128
- Issue: 1
- Pages: 22-3
- Medium: Print
- Language: English
- Citation (JAMA): Mignot Emmanuel, Takahashi Joseph S, et al. A Circadian Sleep Disorder Reveals a Complex Clock.. Cell Jan 2007;128:22-3
Abstract
Circadian rhythms are established by transcription of clock genes and autoregulatory transcriptional feedback loops. In this issue, Xu et al. (2007) characterize mice expressing a human Per2 mutation identified in patients with familial advanced sleep phase syndrome. Their results reveal that PER2 phosphorylation, by CK1delta and other kinases, is surprisingly complex and has opposite effects on PER2 levels and period length.
Mesh Headings (Keywords): Animals, Biological Clocks, Casein Kinase I, Humans, Mice, Models, Biological, Mutation, Nuclear Proteins, Phosphorylation, Sleep Disorders, Circadian Rhythm, Transcription Factors
Check for Full Text / PubMed Unique Identifier (PMID): 17218251
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