Involvement of Phosphatidylinositol-3-kinase and Erk Pathways in the Production of Tgf-beta1 by Macrophages Treated with Liposomes Composed of Phosphatidylserine.
From: School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
FEBS letters
- Publish Date: Jan 2007
- ISSN: 0014-5793
- Volume: 581
- Issue: 2
- Pages: 325-30
- Medium: Print
- Language: English
- Citation (JAMA): Otsuka Masaki, Negishi Yoichi, Aramaki Yukihiko, et al. Involvement of Phosphatidylinositol-3-kinase and Erk Pathways in the Production of Tgf-beta1 by Macrophages Treated with Liposomes Composed of Phosphatidylserine.. FEBS Lett. Jan 2007;581:325-30
Abstract
We explored the involvement of phosphatidylinositol 3-kinase (PI3K) and ERK pathways in the production of TGF-beta1 by macrophages treated with liposomes composed of phosphatidylserine (PS-liposomes). PS-liposomes activated Akt, downstream of the PI3K signal cascade, and ERK which led to the expression of TGF-beta1. PI3K inhibitors, LY294002 and wortmannin, inhibited the activation of Akt and ERK following the treatment with PS-liposomes. These inhibitors also suppressed the production of TGF-beta1. Furthermore, PS-liposomes activated macrophages to induce TGF-beta1 expression through PS-specific receptors. These findings suggested that a PI3K-ERK signaling pathway via the PS-receptor is intimately involved in the production of TGF-beta1 which regulates macrophage functions.
Mesh Headings (Keywords): 1-Phosphatidylinositol 3-Kinase, Animals, Antibodies, Chromones, Enzyme Inhibitors, Extracellular Signal-Regulated MAP Kinases, Liposomes, Macrophages, Male, Mice, Morpholines, Phosphatidylserines, Phosphorylation, Proto-Oncogene Proteins c-akt, Receptors, Cell Surface, Transforming Growth Factor beta1
Check for Full Text / PubMed Unique Identifier (PMID): 17222412
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