Soy Compared to Casein Meal Replacement Shakes with Energy-restricted Diets for Obese Women: Randomized Controlled Trial.
From: Department of Internal Medicine, University of Kentucky, Lexington, KY 40504, USA. jwandersmd@aol.com
Metabolism: clinical and experimental
- Publish Date: Feb 2007
- ISSN: 0026-0495
- Volume: 56
- Issue: 2
- Pages: 280-8
- Medium: Print
- Language: English
- Citation (JAMA): Anderson James W, Fuller Jennifer, Patterson Katy, et al. Soy Compared to Casein Meal Replacement Shakes with Energy-restricted Diets for Obese Women: Randomized Controlled Trial.. Metab. Clin. Exp. Feb 2007;56:280-8
Abstract
Recent studies suggest that obese individuals lose weight more rapidly and lose more total weight with soy protein than with animal protein as a major diet component. The purpose of the present study was to evaluate the weight-loss efficacy and changes in body composition, waist circumference, blood pressure, and levels of plasma glucose, insulin, serum lipids, C-reactive protein, and homocysteine from consumption of either 3 soy shakes or 3 casein shakes daily as part of a 16-week, energy-restricted diet for obese women. Forty-three women with body mass index values of 30 to 40 kg/m(2) were randomized to intensive dietary interventions using either casein (n = 21) or soy (n = 22) shakes. Subjects were instructed to consume 3 shakes, 1 prepackaged entrée, and 5 servings of fruits or vegetables daily to achieve an energy intake of 4.5 to 5.0 MJ/d. Subjects attended classes weekly or biweekly. Weight, body fat, lipid, and glucose measurements were obtained at baseline and at 8 and 16 weeks. For both groups combined, subjects lost 8.1% of initial body weight (7.7 kg) at 8 weeks and 13.4% (12.7 kg) at 16 weeks. Weight loss from baseline did not differ significantly by group and, for completing subjects, was 14.0% +/- 1.2% (mean +/- SE) for casein and 12.8% +/- 1.4% for soy. With the intention-to-treat analysis, weight losses at 16 weeks were 12.5% +/- 1.4% for casein and 11.3% +/- 1.2% for soy. Body fat losses were 23.7% +/- 2.0% for casein and 21.8% +/- 2.4% for soy and did not differ significantly. Both study groups lost significant amounts of weight with a highly structured behavioral program incorporating 4 meal replacements and vegetables and fruits. Differences in weight loss and body composition changes between casein and soy treatments were not significant.
Mesh Headings (Keywords): Adipose Tissue, Adiposity, Adult, Aged, Blood Glucose, Blood Pressure, Body Composition, Body Mass Index, Body Weight, C-Reactive Protein, Caloric Restriction, Caseins, Endpoint Determination, Female, Homocystine, Humans, Insulin, Life Style, Lipids, Middle Aged, Obesity, Patient Compliance, Patient Dropouts, Single-Blind Method, Soy Milk, Waist-Hip Ratio
Check for Full Text / PubMed Unique Identifier (PMID): 17224344
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