Augmentation of 11beta-hydroxysteroid Dehydrogenase Type 1 in Lps-activated J774.1 Macrophages--role of 11beta-hsd1 in Pro-inflammatory Properties in Macrophages.
From: Division of Endocrinology and Metabolism, Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawaharacho, Sakyoku, Kyoto 606-8507, Japan.
FEBS letters
- Publish Date: Feb 2007
- ISSN: 0014-5793
- Volume: 581
- Issue: 3
- Pages: 349-54
- Medium: Print
- Language: English
- Citation (JAMA): Ishii Takako, Masuzaki Hiroaki, Tanaka Tomohiro, et al. Augmentation of 11beta-hydroxysteroid Dehydrogenase Type 1 in Lps-activated J774.1 Macrophages--role of 11beta-hsd1 in Pro-inflammatory Properties in Macrophages.. FEBS Lett. Feb 2007;581:349-54
Abstract
Macrophage infiltration in obese adipose tissue provokes local inflammation and insulin resistance. Evidence has accumulated that activation of 11beta-HSD1 in adipocytes is critically involved in dysfunction of adipose tissue. However, the potential role of 11beta-HSD1 in macrophages still remains unclear. We here demonstrate that a murine macrophage cell line, J774.1 cells expressed 11beta-HSD1 mRNA and reductase activity, both of which were augmented by lipopolysaccharide (LPS)-induced cell activation. Three kinds of pharmacological inhibition of 11beta-HSD1 in LPS-treated macrophages significantly suppressed the expression and secretion of interleukin 1beta, tumor necrosis factor alpha or monocyte chemoattractant protein 1, thereby highlighting a novel role of 11beta-HSD1 in pro-inflammatory properties of activated macrophages.
Mesh Headings (Keywords): 11-beta-Hydroxysteroid Dehydrogenase Type 1, Adipocytes, Animals, Base Sequence, Cell Line, DNA Primers, Dexamethasone, Inflammation, Lipopolysaccharides, Macrophage Activation, Macrophages, Mice, Obesity, RNA, Messenger
Check for Full Text / PubMed Unique Identifier (PMID): 17239856
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