Ucp2 is a Mitochondrial Transporter with an Unusual Very Short Half-life.
From: CNRS-UPR 9078; Université Paris Descartes, Faculté de Médecine, site Necker, 75730 Paris Cedex 15, France.
FEBS letters
- Publish Date: Feb 2007
- ISSN: 0014-5793
- Volume: 581
- Issue: 3
- Pages: 479-82
- Medium: Print
- Language: English
- Citation (JAMA): Rousset Sophie, Mozo Julien, Dujardin Geneviève, et al. Ucp2 is a Mitochondrial Transporter with an Unusual Very Short Half-life.. FEBS Lett. Feb 2007;581:479-82
Abstract
This study focused on the stability of UCP2 (uncoupling protein 2), a mitochondrial carrier located in the inner membrane of mitochondrion. UCP2 is very unstable, with a half-life close to 30min, compared to 30h for its homologue UCP1, a difference that may highlight different physiological functions. Heat production by UCP1 in brown adipocytes is generally a long and adaptive phenomenon, whereas control of mitochondrial ROS by UCP2 needs more subtle regulation. We show that a mutation in UCP2 shown to modify its activity, actually decreases its stability.
Mesh Headings (Keywords): Animals, Base Sequence, CHO Cells, Cell Line, Cricetinae, Cricetulus, DNA, Drug Stability, Half-Life, Humans, Ion Channels, Mice, Mice, Inbred C57BL, Mitochondria, Mitochondrial Proteins, Mutagenesis, Site-Directed, Recombinant Proteins, Saccharomyces cerevisiae
Check for Full Text / PubMed Unique Identifier (PMID): 17240372
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