The Antigenicity of a Plasmodium Vivax Reticulocyte Binding Protein-1 (Pvrbp1) Recombinant Fragment in Humans and Its Immunogenicity and Protection Studies in Aotus Monkeys.
From: Fundacion Instituto de Inmunologia de Colombia (FIDIC), Bogota, Colombia.
Vaccine
- Publish Date: May 2007
- ISSN: 0264-410X
- Volume: 25
- Issue: 18
- Pages: 3713-21
- Medium: Print
- Language: English
- Citation (JAMA): Rojas Caraballo Jose, Delgado Gabriela, Rodriguez Raul, et al. The Antigenicity of a Plasmodium Vivax Reticulocyte Binding Protein-1 (Pvrbp1) Recombinant Fragment in Humans and Its Immunogenicity and Protection Studies in Aotus Monkeys.. Vaccine May 2007;25:3713-21
Abstract
Plasmodium vivax merozoites have been found to specifically invade immature red blood cells (reticulocytes) and this preference has been associated with two proteins named reticulocyte binding protein-1 and protein-2 (PvRBP1 and PvRBP2). Previous reticulocyte binding assays using 15-mer synthetic peptides spanning the entire PvRBP1 sequence have shown that 25 out of the 195 peptides synthesised (grouped into 4 different regions) displayed high affinity binding to reticulocytes. The PvRBP1 region III (amino acids 1998-2348), encompassing 9 of the previously described high-affinity reticulocyte binding peptides, was expressed as a recombinant protein in the present study. This protein has been shown to be antigenic in humans and it has also been able to induce good humoral and cellular immune responses in Aotus nancymaae monkeys. Despite its high immunogenicity, no protective efficacy was observed in the immunised animals.
Mesh Headings (Keywords): Animals, Antibodies, Protozoan, Antigens, Protozoan, Aotidae, Humans, Immunization, Lymphocyte Activation, Malaria Vaccines, Malaria, Vivax, Membrane Proteins, Plasmodium vivax, Protozoan Proteins, Recombinant Proteins
Check for Full Text / PubMed Unique Identifier (PMID): 17240494
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.