Direct Imaging of Hexaamine-ruthenium(Iii) in Domain Boundaries in Monolayers of Single-stranded Dna.
From: Department of Chemistry, Nano DTU, Technical University of Denmark, Building 207, DK-2800 Kgs. Lyngby, Denmark.
Langmuir : the ACS journal of surfaces and colloids
- Publish Date: Jan 2007
- ISSN: 0743-7463
- Volume: 23
- Issue: 3
- Pages: 1410-3
- Medium: Print
- Language: English
- Citation (JAMA): Grubb Mikala, Wackerbarth Hainer, Wengel Jesper, et al. Direct Imaging of Hexaamine-ruthenium(Iii) in Domain Boundaries in Monolayers of Single-stranded Dna.. Jan 2007;23:1410-3
Abstract
We describe adsorption and identification of the binding sites of [Ru(NH3)6]3+ (RuHex) molecules in a closely packed monolayer of a 13-base ss-DNA on Au(111) electrodes by electrochemical in situ scanning tunneling microscopy (STM), cyclic voltammetry and interfacial capacitance data. In situ STM at single-molecule resolution shows that RuHex adsorbs only at the domain borders and near defects. Together with the electrochemical data that show a negative redox potential shift for RuHex adsorbed to DNA strands, this strongly suggests that RuHex binds only to the exposed phosphate groups in the DNA backbone.
Mesh Headings (Keywords): Adsorption, Binding Sites, DNA, Single-Stranded, Electrochemistry, Electrodes, Gold, Microscopy, Scanning Tunneling, Oligodeoxyribonucleotides, Ruthenium Compounds
Check for Full Text / PubMed Unique Identifier (PMID): 17241066
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