• Tsang Chi Kwan
• Zheng X F Steven

Cell cycle (Georgetown, Tex.)

• Publish Date: Jan 2007
• ISSN: 1551-4005
• Volume: 6
• Issue: 1
• Pages: 25-9
• Medium: Internet
• Language: English
• Citation (JAMA): Tsang Chi Kwan, Zheng X F Steven, et al. Tor-in(G) the Nucleus.. Cell Cycle Jan 2007;6:25-9

Abstract

Target of rapamycin (TOR) is a central component of the eukaryotic growth regulatory network. TOR controls the expression of diverse genes by all three RNA polymerases, including ribosome biogenesis, utilization and transport of nutrients, and stress-related genes. Until recently, TOR was thought to be a classical signaling kinase that regulates transcription factors in the cytoplasm. However, our recent study shows that in yeast, TOR dynamically shuttles between the cytoplasm and nucleus, and binds to 35S ribosomal DNA (rDNA) promoter. Importantly, nuclear localization and promoter-binding is crucial for TOR to control RNA polymerase (Pol) I-dependent 35S rDNA transcription. In contrast, either cytoplasmic or nuclear TOR is sufficient to regulate Pol II-dependent transcription. These observations suggest that TOR in the nucleus plays an important role in gene regulation, and that TOR takes a multifaceted approach to control expression of different genes.

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