Sp-tetrakcng: A Novel Cyclic Nucleotide Gated K(+) Channel.
From: Depto. de Genética del Desarrollo y Fisiología Molecular del Instituto de Biotecnología, Universidad Nacional Autónoma de México, Apdo Postal 510-3, Cuernavaca, Morelos 62271, Mexico. bgalindo@cinvestav.mx
Biochemical and biophysical research communications
- Publish Date: Mar 2007
- ISSN: 0006-291X
- Volume: 354
- Issue: 3
- Pages: 668-75
- Medium: Print
- Language: English
- Citation (JAMA): Galindo Blanca Estela, de la Vega-Beltrán José Luis, Labarca Pedro, et al. Sp-tetrakcng: A Novel Cyclic Nucleotide Gated K(+) Channel.. Biochem. Biophys. Res. Commun. Mar 2007;354:668-75
Abstract
The sequence of a novel cGMP-regulated, tetrameric, K(+) selective channel (Sp-tetraKCNG) was discovered in the sea urchin Strongylocentrotus purpuratus. The Sp-tetraKCNG is a single polypeptide made of four KCNG domains similar to voltage-dependent Na(+) and Ca(2+) channels. Each KCNG domain has six transmembrane segments (S1-S6), the ion pore having the K(+) selectivity signature GYGD and a cyclic nucleotide-binding domain (CNBD). This novel channel is evolutionary located between K(+)-selective and voltage-dependent EAG channels and voltage-independent cationic CNG channels. Bilayer reconstitutions demonstrate such a cGMP-regulated K(+) selective channel in sea urchin spermatozoa.
Mesh Headings (Keywords): Animals, Binding Sites, Cations, Cyclic GMP, Lipid Bilayers, Male, Molecular Sequence Data, Potassium Channels, Potassium Channels, Voltage-Gated, Sequence Analysis, Protein, Spermatozoa, Strongylocentrotus purpuratus
Check for Full Text / PubMed Unique Identifier (PMID): 17254550
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