Oncogene-induced Senescence Pathways Weave an Intricate Tapestry.
From: Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd., Berkeley, CA 94720, USA. p_yaswen@lbl.gov
Cell
- Publish Date: Jan 2007
- ISSN: 0092-8674
- Volume: 128
- Issue: 2
- Pages: 233-4
- Medium: Print
- Language: English
- Citation (JAMA): Yaswen Paul, Campisi Judith, et al. Oncogene-induced Senescence Pathways Weave an Intricate Tapestry.. Cell Jan 2007;128:233-4
Abstract
The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.
Mesh Headings (Keywords): Animals, Cell Aging, Cell Proliferation, Cell Transformation, Neoplastic, DNA Damage, Humans, Intracellular Signaling Peptides and Proteins, Mice, Oncogenes, Phosphorylation, Protein-Serine-Threonine Kinases, Signal Transduction, Tumor Suppressor Protein p53
Check for Full Text / PubMed Unique Identifier (PMID): 17254959
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.