Small Molecule Inhibitors of Type Iii Secretion in Yersinia Block the Chlamydia Pneumoniae Infection Cycle.
From: Department of Molecular Biology, Umeå University, SE-90187, Umeå, Sweden.
FEBS letters
- Publish Date: Feb 2007
- ISSN: 0014-5793
- Volume: 581
- Issue: 4
- Pages: 587-95
- Medium: Print
- Language: English
- Citation (JAMA): Bailey Leslie, Gylfe Asa, Sundin Charlotta, et al. Small Molecule Inhibitors of Type Iii Secretion in Yersinia Block the Chlamydia Pneumoniae Infection Cycle.. FEBS Lett. Feb 2007;581:587-95
Abstract
Intracellular parasitism by Chlamydiales is a complex process involving transmission of metabolically inactive particles that differentiate, replicate, and re-differentiate within the host cell. A type three secretion system (T3SS) has been implicated in this process. We have here identified small molecules of a chemical class of acylated hydrazones of salicylaldehydes that specifically blocks the T3SS of Chlamydia. These compounds also affect the developmental cycle showing that the T3SS has a pivotal role in the pathogenesis of Chlamydia. Our results suggest a previously unexplored avenue for development of novel anti-chlamydial drugs.
Mesh Headings (Keywords): Animals, Anti-Bacterial Agents, Bacterial Proteins, Cell Proliferation, Chlamydia Infections, Chlamydia trachomatis, Chlamydophila pneumoniae, Dose-Response Relationship, Drug, Down-Regulation, Epithelial Cells, Gene Expression Regulation, Bacterial, Genes, Bacterial, Hela Cells, Humans, Mice, Transcription, Genetic, Yersinia Infections, Yersinia pseudotuberculosis
Check for Full Text / PubMed Unique Identifier (PMID): 17257594
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