Increased Oxidative Stress in Prepubertal Children Born Small for Gestational Age.
From: Department of Pediatrics, University of Chieti, Via Dei Vestini 15, 66100 Chieti, Italy. amohn@unich.it
The Journal of clinical endocrinology and metabolism
- Publish Date: Apr 2007
- ISSN: 0021-972X
- Volume: 92
- Issue: 4
- Pages: 1372-8
- Medium: Print
- Language: English
- Citation (JAMA): Mohn Angelika, Chiavaroli Valentina, Cerruto Marina, et al. Increased Oxidative Stress in Prepubertal Children Born Small for Gestational Age.. J. Clin. Endocrinol. Metab. Apr 2007;92:1372-8
Abstract
CONTEXT: Low birth weight is associated with an increased risk of metabolic and cardiovascular diseases in adulthood. The development of insulin resistance (IR) seems to play a pivotal role; no data on the oxidant-antioxidant status are available in this risk group. OBJECTIVE: This study is an assessment of oxidant-antioxidant status in prepubertal children born small for gestational age (SGA) in comparison to healthy controls and the relationship to IR. DESIGN: This cross-sectional study compares indexes of IR and oxidant-antioxidant status in three different groups (SGA+, SGA-, controls), with analysis by post hoc and Pearson correlation. SETTING: The study was conducted in the Academic Department of Pediatrics. PARTICIPANTS: A total of 19 SGA+ and 16 SGA- children were compared with 13 controls. INTERVENTION: No intervention was used. MAIN OUTCOME MEASURES: Indexes of IR (glucose to insulin ratio, homeostasis model assessment of IR) were evaluated, and markers of oxidative stress (lag phase, malonildialdehyde, vitamin E) were measured. RESULTS: Homeostasis model assessment of IR was significantly higher in SGA+ than SGA- children (1.32+/-0.9 vs. 0.69+/-0.47; P=0.03) and controls (0.71+/-0.37; P=0.04). Glucose to insulin ratio was significantly lower in SGA+ than SGA- children (12.41+/-5.01 vs. 26.54+/-17.18; P=0.02) and controls (26.96+/-20.70; P=0.04). Lag phase was significantly shorter in SGA+ than SGA- children (24.3+/-4.38 vs. 35.59+/-11.29 min; P=0.003) and controls (45.28+/-7.69 min; P=0.0001) and in SGA- than controls (P=0.01). Malonildialdehyde was significantly higher in SGA+ than SGA- children (0.79+/-0.3 vs. 0.6+/-0.1 nmol/mg; P=0.03) and controls (0.36+/-0.04 nmol/mg; P=0.0001) and in SGA- children than controls (P=0.02). Vitamin E was significantly reduced in SGA+ children than controls (27.54+/-7.9 vs. 43.23+/-11.32 micromol/liter; P=0.002). CONCLUSION: Oxidative stress is present in both SGA+ and SGA- children, with a continuous alteration in relation to IR. Therefore, catch-up growth might exert the greatest influence in the development of future diseases.
Mesh Headings (Keywords): Blood Glucose, Body Composition, Body Height, C-Peptide, Child, Child, Preschool, Electric Impedance, European Continental Ancestry Group, Female, Humans, Infant, Newborn, Infant, Small for Gestational Age, Insulin Resistance, Lipid Peroxidation, Lipoproteins, LDL, Male, Oxidative Stress, Reference Values
Check for Full Text / PubMed Unique Identifier (PMID): 17264184
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.