Aminoglycoside-induced Ototoxicity.
From: Inonu University, Department of Otorhinolaryngology, Malatya, Turkey. erolselimoglu@hotmail.com
Current pharmaceutical design
- Publish Date: 2007
- ISSN: 1873-4286
- Volume: 13
- Issue: 1
- Pages: 119-26
- Medium: Internet
- Language: English
- Citation (JAMA): Selimoglu Erol, et al. Aminoglycoside-induced Ototoxicity.. Curr. Pharm. Des. 2007;13:119-26
Abstract
It has long been known that the major irreversible toxicity of aminoglycosides is ototoxicity. Among them, streptomycin and gentamicin are primarily vestibulotoxic, whereas amikacin, neomycin, dihydrosterptomycin, and kanamicin are primarily cochleotoxic. Cochlear damage can produce permanent hearing loss, and damage to the vestibular apparatus results in dizziness, ataxia, and/or nystagmus. Aminoglycosides appear to generate free radicals within the inner ear, with subsequent permanent damage to sensory cells and neurons, resulting in permanent hearing loss. Two mutations in the mitochondrial 12S ribosomal RNA gene have been previously reported to predispose carriers to aminoglycoside-induced ototoxicity. As aminoglycosides are indispensable agents both in the treatment of infections and Meniere’s disease, a great effort has been made to develop strategies to prevent aminoglycoside ototoxicity. Anti-free radical agents, such as salicylate, have been shown to attenuate the ototoxic effects of aminoglycosides. In this paper, incidence, predisposition, mechanism, and prevention of aminoglycoside-induced ototoxicity is discussed in the light of literature data.
Mesh Headings (Keywords): Aminoglycosides, Animals, Anti-Bacterial Agents, Cochlea, Dose-Response Relationship, Drug, Drug Administration Schedule, Genetic Predisposition to Disease, Genetic Screening, Hair Cells, Auditory, Hearing Disorders, Humans, Incidence, Meniere Disease, Mutation, RNA, RNA, Ribosomal, Risk Assessment, Risk Factors, Vestibule, Labyrinth
Check for Full Text / PubMed Unique Identifier (PMID): 17266591
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.