• Anasetti Claudio
• Mulé James J

The Journal of clinical investigation

• Publish Date: Feb 2007
• ISSN: 0021-9738
• Volume: 117
• Issue: 2
• Pages: 306-10
• Medium: Print
• Language: English
• Citation (JAMA): Anasetti Claudio, Mulé James J, et al. To Ablate or Not to Ablate? Hscs in the T Cell Driver's Seat.. J. Clin. Invest. Feb 2007;117:306-10

Abstract

The combination of the induction of lymphopenia and vaccination and/or T cell transfer is garnering much attention for cancer treatment. Preclinical studies have shown that the induction of lymphopenia by chemotherapy or radiation can enhance the antitumor efficacy of several distinct, cell-based immunotherapeutic approaches. The mechanism(s) by which such enhancement is achieved are being intensively studied, yet there is much opportunity for improvement. The animal studies reported by Wrzesinski and colleagues in this issue of the JCI are a promising and timely step in this direction (see the related article beginning on page 492). The authors have evaluated both the effect of increasing the intensity of lymphodepletion and the influence of HSC transfer on the in vivo function of adoptively transferred CD8(+) T cells. We discuss their results in light of the evolving field and their implications for advancing cell-based immunotherapies for cancer.

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