Fruit and Vegetable Consumption, Intake of Micronutrients, and Benign Prostatic Hyperplasia in Us Men.
From: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
The American journal of clinical nutrition
- Publish Date: Feb 2007
- ISSN: 0002-9165
- Volume: 85
- Issue: 2
- Pages: 523-9
- Medium: Print
- Language: English
- Citation (JAMA): Rohrmann Sabine, Giovannucci Edward, Willett Walter C, et al. Fruit and Vegetable Consumption, Intake of Micronutrients, and Benign Prostatic Hyperplasia in Us Men.. Am. J. Clin. Nutr. Feb 2007;85:523-9
Abstract
BACKGROUND: Nutrients with antioxidant properties or that influence cell growth and differentiation might reduce the risk of benign prostatic hyperplasia (BPH). OBJECTIVE: The objective was to evaluate the association of fruit, vegetable, and micronutrient intakes with BPH. DESIGN: The participants were members of the Health Professionals Follow-Up Study and were aged 46-81 y in 1992. In 1992 and biennially thereafter, the men reported having surgery for an enlarged prostate, and in 1992 and on 3 subsequent questionnaires they completed the American Urological Association symptom index (AUASI). BPH cases were men who reported having surgery or who had an AUASI score of 15-35 (n = 6092). Control subjects were men who had not had surgery and never had an AUASI score >7 (n = 18 373). Men with a score of 8-14 were excluded (n = 7800). Intakes of fruit, vegetables, and antioxidants were assessed with a food-frequency questionnaire in 1986. We calculated odds ratios (ORs) of BPH and 95% CIs using logistic regression. RESULTS: Vegetable consumption was inversely associated with BPH (fifth compared with first quintile-OR: 0.89; 95% CI: 0.80, 0.99; P for trend = 0.03), whereas fruit intake was not. Consumption of fruit and vegetables rich in beta-carotene (P for trend = 0.004), lutein (P for trend = 0.0004), or vitamin C (P for trend = 0.05) was inversely related to BPH. With increasing vitamin C intake from foods, men were less likely to have BPH (P for trend = 0.0009). Neither alpha- nor gamma-tocopherol intake from foods was associated with BPH (P for trend = 0.05 and 0.84, respectively). CONCLUSION: Our findings are consistent with the hypothesis that a diet rich in vegetables may reduce the occurrence of BPH.
Mesh Headings (Keywords): Aged, Aged, 80 and over, Fruit, Humans, Male, Micronutrients, Middle Aged, Odds Ratio, Prostatic Hyperplasia, Risk Factors, United States, Vegetables
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