The Colocalization of Cgrp Receptor and Ampa Receptor in the Spinal Dorsal Horn Neuron of Rat: a Morphological and Electrophysiological Study.
From: Neurobiology Laboratory and National Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, PR China.
Neuroscience letters
- Publish Date: Mar 2007
- ISSN: 0304-3940
- Volume: 414
- Issue: 3
- Pages: 237-41
- Medium: Print
- Language: English
- Citation (JAMA): Gu Xing-Long, Yu Long-Chuan, et al. The Colocalization of Cgrp Receptor and Ampa Receptor in the Spinal Dorsal Horn Neuron of Rat: a Morphological and Electrophysiological Study.. Neurosci. Lett. Mar 2007;414:237-41
Abstract
Both the calcitonin gene-related peptide (CGRP) receptor and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor are involved in the transmission of sensory information from primary afferent to the spinal cord. The present study found that there was a colocalization of CGRP receptor and AMPA receptor in a single spinal dorsal horn neuron in rat determined by double immunofluorescence labeling image methods. Furthermore, our results showed that the evoked discharge frequency of the wide dynamic range (WDR) neuron, one type of the dorsal horn neurons, increased significantly after micro-iontophoretic delivery of CGRP or AMPA alone tested by extracellular recording, indicating a functional colocalization of CGRP receptor and AMPA receptor in a single spinal dorsal horn neuron. The results of the present study found a morphological and functional colocalization of the CGRP receptor and AMPA receptor in a single dorsal horn neuron that involved in the transmission and modulation of sensory information from primary afferent to the spinal cord in rats.
Mesh Headings (Keywords): Afferent Pathways, Animals, Calcitonin Gene-Related Peptide, Evoked Potentials, Excitatory Amino Acid Agonists, Fluorescent Antibody Technique, Glutamic Acid, Male, Nociceptors, Pain, Posterior Horn Cells, Rats, Rats, Wistar, Receptors, AMPA, Receptors, Calcitonin Gene-Related Peptide, Sensation, Spinal Nerve Roots, Synaptic Transmission, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Check for Full Text / PubMed Unique Identifier (PMID): 17287081
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.