Primary Sensory Neurons Containing Choline Acetyltransferase of the Peripheral Type in the Rat Trigeminal Ganglion and Their Relation to Neuropeptides-, Calbindin- and Nitric Oxide Synthase-containing Cells.
From: Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. yasuhara@bele.shiga-med.ac.jp
Brain research
- Publish Date: Apr 2007
- ISSN: 0006-8993
- Volume: 1141
- Issue:
- Pages: 92-8
- Medium: Print
- Language: English
- Citation (JAMA): Yasuhara Osamu, Aimi Yoshinari, Shibano Akira, et al. Primary Sensory Neurons Containing Choline Acetyltransferase of the Peripheral Type in the Rat Trigeminal Ganglion and Their Relation to Neuropeptides-, Calbindin- and Nitric Oxide Synthase-containing Cells.. Brain Res. Apr 2007;1141:92-8
Abstract
We have previously demonstrated that a variant form of choline acetyltransferase (pChAT) is expressed in rat trigeminal neurons. To assess the significance of pChAT in sensory functions, we characterized immunohistochemically pChAT-positive trigeminal neurons in the rat. pChAT-immunoreactivity was observed in a rather uniform pattern in about half of all trigeminal neurons throughout the trigeminal ganglion. The majority of pChAT-positive neurons had small to medium-sized cell bodies. Double immunofluorescent study showed that more than 90% of substance P (SP)-positive trigeminal cells and about 80% of calcitonin gene-related peptide (CGRP)-positive cells exhibited pChAT-immunoreactivity. pChAT-positive cells formed a larger population of neurons than SP-positive or CGRP-positive cells, but they were a different population from calbindin-D(28k)-positive neurons. In addition, pChAT-immunoreactivity was present in a subset of neurons positive for neuronal nitric oxide synthase. The present results suggest that pChAT plays roles not only in nociception, but also in other sensory functions such as mechanoreception mediating tactile sensation.
Mesh Headings (Keywords): Animals, Calcitonin Gene-Related Peptide, Calcium-Binding Protein, Vitamin D-Dependent, Choline O-Acetyltransferase, Immunohistochemistry, Male, Neurons, Afferent, Neuropeptides, Nitric Oxide Synthase, Rats, Trigeminal Ganglion
Check for Full Text / PubMed Unique Identifier (PMID): 17291466
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.