Beta-catenin Regulates P-cadherin Expression in Mammary Basal Epithelial Cells.
From: UMR 144, CNRS-Institut Curie, Section de Recherche, 26, rue d’Ulm, 75248 Paris, Cedex 05, France. faraldo@curie.fr
FEBS letters
- Publish Date: Mar 2007
- ISSN: 0014-5793
- Volume: 581
- Issue: 5
- Pages: 831-6
- Medium: Print
- Language: English
- Citation (JAMA): Faraldo Marisa M, Teulière Jérôme, Deugnier Marie-Ange, et al. Beta-catenin Regulates P-cadherin Expression in Mammary Basal Epithelial Cells.. FEBS Lett. Mar 2007;581:831-6
Abstract
P-cadherin expression is restricted to the basal layer of stratified epithelia including that of the mammary gland. Although evidence for an important role of P-cadherin in mammary morphogenesis and tumorigenesis is increasing, the mechanisms that regulate its expression are poorly understood. We show that in basal mammary epithelial cells, beta-catenin is associated with the P-cadherin promoter and activates its expression independently of LEF/TCF in a cell-type specific manner. Down-regulation of endogenous beta-catenin levels by RNA interference technique inhibited P-cadherin promoter activity. In vivo, in skin and mammary gland of mutant mice, activation of beta-catenin signalling correlates with up-regulation of P-cadherin expression. These data suggest that beta-catenin-dependent modulation of P-cadherin expression can contribute to the establishment of the basal phenotype.
Mesh Headings (Keywords): Animals, Base Sequence, Binding Sites, Cadherins, Cell Line, Cell Nucleus, DNA Primers, Epithelial Cells, Female, Gene Expression Regulation, Mammary Glands, Animal, Mice, Mice, Knockout, Mice, Transgenic, Promoter Regions (Genetics), RNA Interference, RNA, Messenger, Signal Transduction, Skin, TCF Transcription Factors, beta Catenin
Check for Full Text / PubMed Unique Identifier (PMID): 17292359
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