Inverse Changes in Fetal Insulin-like Growth Factor (Igf)-1 and Igf Binding Protein-1 in Association with Higher Birth Weight in Maternal Diabetes.
From: BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, UK. R.Lindsay@clinmed.gla.ac.uk
Clinical endocrinology
- Publish Date: Mar 2007
- ISSN: 0300-0664
- Volume: 66
- Issue: 3
- Pages: 322-8
- Medium: Print
- Language: English
- Citation (JAMA): Lindsay Robert S, Westgate J A, Beattie J, et al. Inverse Changes in Fetal Insulin-like Growth Factor (Igf)-1 and Igf Binding Protein-1 in Association with Higher Birth Weight in Maternal Diabetes.. Clin. Endocrinol. (Oxf) Mar 2007;66:322-8
Abstract
OBJECTIVE: The insulin like growth factor (IGF) system plays a key role in regulating fetal growth, is metabolically regulated, and may influence development of increased birth weight in offspring of mothers with diabetes. We examined IGF-1 and IGF binding protein-1 (IGFBP-1) concentrations in cord blood samples from offspring of mothers with gestational and type 2 diabetes. DESIGN AND PATIENTS: Case-control study of Maori and Pacific Island mothers recruited prospectively at Middlemore Hospital, South Auckland, New Zealand. MEASUREMENTS: Cord blood (for insulin, IGF-1 and IGFBP-1) was taken from umbilical vein at birth from singleton babies born after 32 weeks of gestation from138 mothers with gestational diabetes (GDM), 39 mothers with type 2 diabetes (T2DM) and 95 control mothers. RESULTS: Babies born to mothers with both GDM and T2DM had significantly increased birth weight (Z-score birth weight mean +/- SD: GDM 0.94 +/- 1.31, T2DM 0.53 +/- 1.1) compared to controls (Z-score birth weight -0.08 +/- 1.10). IGFBP-1 was significantly reduced in both diabetic groups (median interquartile range: GDM 67(31-137) ng/ml, T2DM 59(29-105) ng/ml, control 114(56-249) ng/ml). Cord IGF-1 was significantly increased in cord blood of infants of mothers with GDM (42.2 +/- 16.3 ng/ml vs. control 34.7 +/- 18.5 ng/ml) but not T2DM (38.7 +/- 17.4 ng/ml). In all offspring, IGF-1 and IGFBP-1 were positively and negatively correlated with birth weight, respectively. CONCLUSIONS: Maternal diabetes results in inverse changes of circulating fetal IGF-1 and IGFBP-1 at birth. A decrease in circulating IGFBP-1 and to a lesser extent an increase in circulating IGF-1 may present an important mechanism that contributes to increased birth weight in diabetic pregnancies.
Mesh Headings (Keywords): Adult, Birth Weight, Blood Glucose, Case-Control Studies, Chi-Square Distribution, Diabetes Mellitus, Type 2, Diabetes, Gestational, Female, Fetal Blood, Fetal Macrosomia, Humans, Infant, Newborn, Insulin, Insulin-Like Growth Factor Binding Protein 1, Insulin-Like Growth Factor I, Linear Models, Postpartum Period, Pregnancy, Pregnancy in Diabetics
Check for Full Text / PubMed Unique Identifier (PMID): 17302863
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