P53 Directs Focused Genomic Responses in Drosophila.
From: Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Oncogene
- Publish Date: Aug 2007
- ISSN: 0950-9232
- Volume: 26
- Issue: 36
- Pages: 5184-93
- Medium: Print
- Language: English
- Citation (JAMA): Akdemir F, Christich A, Sogame N, et al. P53 Directs Focused Genomic Responses in Drosophila.. Oncogene Aug 2007;26:5184-93
Abstract
p53 is a fundamental determinant of cancer susceptibility and other age-related pathologies. Similar to mammalian counterparts, Drosophila p53 integrates stress signals and elicits apoptotic responses that maintain genomic stability. To illuminate core-adaptive functions controlled by this gene family, we examined the Drosophila p53 regulatory network at a genomic scale. In development, the absence of p53 impacted constitutive expression for a surprisingly broad scope of genes. By contrast, stimulus-dependent responses governed by Drosophila p53 were limited in scope. The vast majority of stress responders were induced and p53 dependent (RIPD) genes. The signature set of 29 ‘high stringency’ RIPD genes identified here were enriched for intronless loci, with a non-uniform distribution that includes a recently evolved cluster unique to Drosophila melanogaster. Two RIPD genes, with known and unknown biochemical activities, were functionally examined. One RIPD gene, designated XRP1, maintains genome stability after genotoxic challenge and prevents cell proliferation upon induced expression. A second gene, RnrL, is an apoptogenic effector required for caspase activation in a model of p53-dependent killing. Together, these studies identify ancient and convergent features of the p53 regulatory network.
Mesh Headings (Keywords): Animals, Cells, Cultured, Drosophila melanogaster, Gene Expression Profiling, Genome, Tumor Suppressor Protein p53
Check for Full Text / PubMed Unique Identifier (PMID): 17310982
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.