Cc Chemokine Receptor 7 Contributes to Gi-dependent T Cell Motility in the Lymph Node.
From: Department of Microbiology and Immunology and Howard Hughes Medical Institute, University of California-San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
Journal of immunology (Baltimore, Md. : 1950)
- Publish Date: Mar 2007
- ISSN: 0022-1767
- Volume: 178
- Issue: 5
- Pages: 2973-8
- Medium: Print
- Language: English
- Citation (JAMA): Okada Takaharu, Cyster Jason G, et al. Cc Chemokine Receptor 7 Contributes to Gi-dependent T Cell Motility in the Lymph Node.. J. Immunol. Mar 2007;178:2973-8
Abstract
Naive T cells migrate extensively within lymph node (LN) T zones to scan for Ag-bearing dendritic cells. However, the extracellular signals controlling T cell motility in LNs are not well defined. In this study, by real-time imaging of LNs, we show that the inhibition of Gi signaling in T cells severely impairs their migration. The chemokine CCL21, a ligand of CCR7, strongly induces chemokinesis in vitro, and T cell motility in LNs from CCR7 ligand-deficient plt/plt mice was reduced. CCR7-deficient T cells in wild-type LNs showed a similar reduction in motility, and antagonism of CXCR4 function did not further decrease their motility. The effect of CCR7 or CCR7-ligand deficiency could account for approximately 40% of the Gi-dependent motility. These results reveal a role for CCR7 in promoting T cell migration within lymphoid organ T zones, and they suggest the additional involvement of novel Gi-coupled receptors in promoting T cell motility at these sites.
Mesh Headings (Keywords): Animals, Chemokine CCL21, Chemokines, CC, Chemotaxis, Dendritic Cells, GTP-Binding Protein alpha Subunits, Gi-Go, Lymph Nodes, Mice, Microscopy, Fluorescence, Multiphoton, Receptors, CCR4, Receptors, CCR7, Receptors, Chemokine, T-Lymphocytes
Check for Full Text / PubMed Unique Identifier (PMID): 17312142
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