Antibiotic Strategies in the Treatment of Infection in Critically Ill Patients
From: Odense Universitetshospital, Anaestesiologisk-intensiv Afdeling V, Odense C. jens.schierbeck@ouh.fyns-amt.dk
Ugeskrift for laeger
- Publish Date: Feb 2007
- ISSN: 1603-6824
- Volume: 169
- Issue: 8
- Pages: 699-702
- Medium: Internet
- Language:
- Citation (JAMA): Schierbeck Jens, Kolmos Hans Jørn J, et al. Antibiotic Strategies in the Treatment of Infection in Critically Ill Patients. Ugeskr. Laeg. Feb 2007;169:699-702
Abstract
Inappropriate antimicrobial therapy of pneumonia, severe sepsis and bacteraemia is associated with high mortality. Adjustment of insufficient initial antibiotics after susceptibility testing does not reduce mortality. Guidelines on critically ill patients should focus on antibiograms for each intensive care unit to ensure full coverage of initial therapy with a broad-spectrum antibiotic with high tissue penetration, minimal organ toxicity and low risk of resistance development. Early reassessment and withdrawal of antibiotics, if not indicated, are important elements in reducing antibiotic resistance. The initial broad-spectrum should be narrowed according to bacterial susceptibility data. This evidence-based intervention ensures appropriate antimicrobial treatment to critically ill patients to improve outcome and reduction of the use of broad-spectrum antibiotics.
Mesh Headings (Keywords): Anti-Bacterial Agents, Bacteremia, Critical Illness, Cross Infection, Drug Resistance, Bacterial, Evidence-Based Medicine, Humans, Intensive Care, Microbial Sensitivity Tests, Pneumonia, Bacterial, Practice Guidelines as Topic, Risk Factors, Sepsis, Treatment Outcome
Check for Full Text / PubMed Unique Identifier (PMID): 17313920
This abstract is part of PubMed, a service of the U.S. National Library of Medicine. PubMed includes more than 17 million citations from MEDLINE and other life science journals for biomedical articles. See Copyright and Disclaimers.
Linked medical terms appearing on this page are added by Healia to help readers find more information and are not part of the original PubMed document.
The data herein was last updated on July 8th, 2008 and may not reflect the most current and accurate data available from NLM.